Topical Estrogen Gives Better Protection Against Heart Disease – A compelling recent study in the European Heart Journal, September 2008 was designed to answer the question: Does estrogen cause heart attacks? A group of 698,098 healthy Danish postmenopausal women were followed for six years. The women were divided into groups by the TYPE of HT they were taking and compared to those women on no HT. The women on oral estrogen plus progestin had a 35% HIGHER occurrence of heart attacks as compared to women on no HT. The women on topical estrogen (patches, gels, NOT COMPOUNDED) had a 38% LOWER occurrence of heart attacks compared to women on no HT. So in essence, oral estrogen causes heart attacks while topical estrogen protects against heart attacks!